This Meat Lovers Pizza Casserole is the ultimate comfort food, loaded with layers of savory meats, pasta, pizza sauce, and gooey melted cheese. Perfect for family dinners, gatherings, or when you’re craving pizza in a heartier form, this casserole is both filling and easy to prepare. It combines all your favorite pizza flavors in one warm, cheesy, oven-baked dish.
Why You’ll Love This Recipe
Pizza-Inspired – All the flavors of your favorite meat lovers pizza in casserole form.
Protein-Packed – Sausage, pepperoni, and ground beef make it hearty and satisfying.
Cheesy & Comforting – Melted mozzarella brings everything together.
Family-Friendly – Easy to make, serve, and reheat for busy weeknights.
Ingredients
- 12 oz pasta (penne or rotini)
- 1 lb ground beef
- ½ lb Italian sausage
- 1 cup pepperoni slices
- 3 cups pizza sauce (or marinara)
- 2 cups shredded mozzarella cheese
- ½ cup grated Parmesan cheese
- 1 tsp Italian seasoning
- ½ tsp garlic powder
- Salt and pepper to taste
Instructions
- Cook the Pasta
Boil pasta according to package directions until al dente. Drain and set aside. - Cook the Meat
In a large skillet, cook ground beef and Italian sausage over medium heat until browned. Drain excess fat and season with garlic powder, Italian seasoning, salt, and pepper. - Assemble the Casserole
In a greased 9×13 baking dish, combine cooked pasta, meat mixture, and pizza sauce. Mix well. Stir in half of the mozzarella and Parmesan cheese. - Top and Bake
Spread mixture evenly in the dish. Top with remaining mozzarella, Parmesan, and pepperoni slices. Bake uncovered at 375°F (190°C) for 20–25 minutes, until cheese is bubbly and golden. - Serve
Let cool slightly before serving. Slice into portions and enjoy warm.

Nutritional Information
Calories: ~420
Protein: 27g
Fat: 21g
Carbohydrates: 30g
Sugar: 6g
Fiber: 2g
Tips for Success
- Cook Pasta Al Dente – It will continue to cook in the oven, so keep it slightly firm.
- Mix Cheese Layers – Stir some cheese into the casserole and leave plenty on top for that gooey pizza finish.
- Add Extra Toppings – Try adding bacon, mushrooms, or bell peppers for more pizza flavors.
Why This Recipe Works
By combining pasta, pizza sauce, hearty meats, and layers of cheese, this casserole delivers the same bold flavors of a pizza in a filling, family-friendly dish. The baked layers create a comforting, melty, and savory meal that’s easy to prepare and enjoy.
This Meat Lovers Pizza Casserole is a hearty, cheesy, and flavor-packed dish that satisfies pizza cravings in casserole form. Easy to make, customizable, and perfect for feeding a crowd, it’s a recipe you’ll want to keep on repeat for family dinners and gatherings.
Meat Lovers Pizza Casserole – Hearty, Cheesy, and Flavor-Packed
6-8
15
minutes25
420
kcalA hearty casserole loaded with pasta, beef, sausage, pepperoni, pizza sauce, and melted cheese — all the flavors of a meat lovers pizza baked into one comforting dish.
Ingredients
12 oz pasta (penne or rotini)
1 lb ground beef
½ lb Italian sausage
1 cup pepperoni slices
3 cups pizza sauce (or marinara)
2 cups shredded mozzarella cheese
½ cup grated Parmesan cheese
1 tsp Italian seasoning
½ tsp garlic powder
Salt and pepper to taste
Instructions
- Cook the Pasta
Boil pasta according to package directions until al dente. Drain and set aside. - Cook the Meat
In a large skillet, cook ground beef and Italian sausage over medium heat until browned. Drain excess fat and season with garlic powder, Italian seasoning, salt, and pepper. - Assemble the Casserole
In a greased 9×13 baking dish, combine cooked pasta, meat mixture, and pizza sauce. Mix well. Stir in half of the mozzarella and Parmesan cheese. - Top and Bake
Spread mixture evenly in the dish. Top with remaining mozzarella, Parmesan, and pepperoni slices. Bake uncovered at 375°F (190°C) for 20–25 minutes, until cheese is bubbly and golden. - Serve
Let cool slightly before serving. Slice into portions and enjoy warm.
Notes
- Cook Pasta Al Dente – It will continue to cook in the oven, so keep it slightly firm.
Mix Cheese Layers – Stir some cheese into the casserole and leave plenty on top for that gooey pizza finish.
Add Extra Toppings – Try adding bacon, mushrooms, or bell peppers for more pizza flavors.